學生姓名:
李芳頡
指導教授:
黃崇雄
學期:
114下
摘 要:
Inflammation is a complex biological response to harmful stimuli, infection, or tissue injury. However, dysregulated inflammatory responses can contribute to the development of chronic diseases and tissue damage. Curcumin, a natural polyphenolic compound derived from turmeric, has been widely reported to possess anti16 inflammatory, antioxidant, and anticancer activities. Despit its therapeutic potential, the clinical application of curcumin is limited due to its poor water solubility, low bioavailability, and chemical instability. Nanoemulsion technology has emerged as a promising strategy to improve the stability and delivery efficiency of hydrophobic compounds. This study reviews the potential anti-inflammatory effects of curcumin nanoemulsions based on two recent studies. The results demonstrate that curcumin nanoemulsion (CUR-NE) exhibits excellent physicochemical stability and sustained drug release properties. In vitro experiments showed that CUR-NE was efficiently internalized by LPS-activated RAW 264.7 macrophages and significantly reduced the production of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, while increasing the release of the anti-inflammatory cytokine IL-10. Furthermore, in vivo studies revealed that CUR-NE reduced macrophage infiltration at inflammatory sites and alleviated tissue edema and inflammation. Overall, nanoemulsion-based delivery systems significantly enhance the anti-inflammatory efficacy of curcumin and may provide a promising therapeutic strategy for inflammatory diseases.
李芳頡.pdf