學生姓名:
姜采萱
指導教授:
黃崇雄
學期:
114下
摘 要:
In recent years, the incidence of melanoma has steadily increased, and due to its high metastatic potential and mortality rate, it has become one of the most aggressive forms of skin cancer. The efficacy of current treatments, including targeted therapy and immunotherapy, is often limited by individual variability and associated adverse effects. Therefore, the development of natural compounds with low toxicity and therapeutic potential has gained increasing attention. Brown seaweeds are rich in bioactive polysaccharides, among which fucoidan has been reported to possess antitumor, anti20 inflammatory, and immunomodulatory properties. This report integrates two selected studies to investigate the effects of brown algae–derived polysaccharides on melanoma. Experimental results demonstrate that polysaccharides extracted from the sporophyll of Undaria pinnatifida effectively inhibited α-Melanocyte-stimulating hormone (α-MSH) -induced melanogenesis in B16-F10 melanoma cells, accompanied by reduced expression of tyrosinase, tyrosinase 、 tyrosinase-related protein 1 (TRP-1) , and tyrosinase-related protein 2 (TRP-2). In addition, fucoidan (Fucan A) derived from Spatoglossum schröederi suppressed cell proliferation, induced cell cycle regulation, and significantly reduced tumor growth, angiogenesis, and lung metastasis in vivo. These findings suggest that brown algae–derived polysaccharides can modulate melanogenesis and tumor progression, highlighting their potential as natural therapeutic agents for melanoma treatment.
姜采萱.pdf