學生姓名:
唐鈺婷
指導教授:
黃意真
學期:
109上
摘 要:
Oral delivery is the most common method for drug administration. However, poor solubility, stability, and bioavailability of many drugs make achieving therapeutic levels via the gastrointestinal (GI) tract challenging. However, Nanoparticle drug carriers that can shield drugs from degradation and deliver them to intended sites within the GI tract may enable more efficient and sustained drug delivery. This study aimed to discuss nanoparticles self-assembled from fucoidan and chitosan to improve their physicochemical properties as oral delivery systems, control its release under simulated gastrointestinal environment and preserve therapeutic effects. Three different ratio fucoidan/chitosan (F/C) nanoparticles were used to encapsulate quercetin. The results show that the 1F/1C ratio nanoparticle became more unstable as the pH increased from 2.5 to 7.4, while the 3F/1C and 5F/1C nanoparticles retained their initial characteristics. This result indicates that the latter nanoparticles were stable along the gastrointestinal tract. Trimethyl chitosan (TMC) shows excellent mucoadhesive and absorption-enhancing properties while fucoidan (FD) has hypoglycemic effects and can prevent diabetes-related complications. TMC and FD self-assembled into spherical nanoparticles (NPs) for insulin encapsulation. TMC combined with FD can be developed to a multifunctional nanoplatform for enhancing the transepithelial permeation of insulin and inhibiting the α-glucosidase activity. TMC/FD NPs protected insulin against degradation by releasing insulin in a pH-dependent manner in the gastrointestinal tract fluids.
摘要_江和光.pdf