Explore the prevalence of antibiotic resistance in Gram-negative bacteria in poultry and the environment

學生姓名: 徐珮珊
指導教授: 林泓廷
學期: 110下
摘  要: Foodborne diseases are an acknowledged public health challenge worldwide. A variety of antimicrobials are used in poultry for disease control, prophylaxis, and growth promotion. Indiscriminate use of antimicrobials in food animals has resulted in the emergence of multiple
antibiotic-resistant strains of foodborne pathogens, such as Salmonella, Escherichia coli (E.coli) , and Campylobacter, as well as bacteria endogenous to the microfloras of animals. In humans, Salmonella spp. is one of the most common pathogens causing bacterial foodborne
diseases, while in animals, salmonellosis is a common zoonotic disease worldwide. Escherichia coli, a widespread pathogenic bacterium in humans and animals, causes a variety of diseases that are difficult to control and results in a large number of deaths in poultry populations, leading to significant economic losses in the poultry industry. The first study was to monitoring the resistance of E. coli throughout the broiler fattening period is therefore of great significance for both the poultry industry and public health. The result show that during the entire broiler fattening cycle, antimicrobial resistance and drug resistance genes in E. coli were least common in the early fattening stage. Antibiotic resistance was common in E. coli present in poultry farms in Shandong Province, most likely as a result of contaminated farm environments and the extensive use of antibiotics. The aim of the second study was to investigate the prevalence of antimicrobial resistance of Salmonella isolated from turkey farms in Taiwan. This study demonstrates that imported and fattening turkeys could be a reservoir for Salmonella isolates resistant to multiple antimicrobials. These results also reinforce the need to develop strategies and implement specific control procedures to reduce the development of antimicrobial resistance.