Fatty Acid in Cordyceps and Flavonoids from Houttuynia cordata on Immunomodulatory Effects Against Influenza A Virus

學生姓名: 李昱誼

指導教授: 吳彰哲

學　　期: 112上

摘　　要: Influenza is a viral infectious disease. Influenza can be categorized into four types, namely A, B, C, and D, based on their protein antigens. Influenza typically causes inflammation and lung damage during the infection process, while some studies have found that traditional Chinese medicine are beneficial to these symptoms. (2Z,4E)-deca-2,4-dienoic acid (DDEA) does not inhibit the primary target of the
influenza virus replication in A549 cells and U937 macrophages. DDEA showed a significant inhibition on influenza A virus PR8-induced cytokine production in a dose dependent manner in A549 cells and U937 marophages. DDEA inhibit the TLR-3, RIG-I, and IFN signaling pathways activated by the influenza A virus. Flavonoid in Houttuynia cordata (HCF) were identified as 8.8% rutin, 26.7% hyperin, 9.9%
isoquercitrin, and 31.7% quercitrin. HCF effectively reduced the mortality rate. HCF alleviated lung inflammation and lung damage induced by influenza A virus in mice. HCF inhibits viral NA activity and host TLR signaling, with hyperin and quercitrin playing key roles in HCF. The novel Fatty acid from Chinese Cordyceps inhibits proinflammatory cytokine expressions by disrupting the TLR-3, RIG-I, and IFN
signaling pathways activated by the influenza A virus. Flavonoid compounds in Houttuynia cordata inhibit viral NA activity and host TLR signaling. These extracts have potential therapeutic effects against influenza A virus.