Regulation of lipid metabolism and anti-inflammatory effects of kombucha
學生姓名:
劉愛德
指導教授:
蔡國珍
學期:
113上
摘 要:
The 2017-2020 National Nutrition and Health Survey in Taiwan revealed that 50.7% of adults were overweight or obese, primarily due to high-fat and high-fructose diets, which can also trigger inflammatory diseases. Kombucha, a fermented beverage made from black tea, yeast, acetic acid bacteria, and lactic acid bacteria, is rich in bioactive compounds with potential benefits for improving diabetes, protecting the liver, antioxidant effects, anti-inflammatory properties, and anticancer potential. This report aims to explore the effects of black and green tea kombucha on regulating lipid metabolism and reducing inflammation. In Drosophila with Lipid storage droplet-1 dysfunction-induced inflammation, kombucha significantly reduced reactive oxygen species production, inhibited the expression of c-Jun N-terminal kinases inflammatory pathway genes (Eiger, Toll-like receptors, Spatzle, Upd1, and Upd3), and promoted the expression of the lipase gene bmm, thereby decreasing inflammation and triglyceride accumulation. In Wistar rats fed a high-fat, high-fructose diet, kombucha effectively regulated abnormal glucose metabolism and the expression of lipid synthesis26 related genes such as sterol regulatory element-binding protein 1c, acetyl-coA carboxylase, carnitine palmitoyltransferase 1, and adiponectin-receptor 2. It also reduced fat accumulation, improved hepatic steatosis, enhanced plasma superoxide dismutase, catalase activities, and total antioxidant capacity, while lowering nitric oxide levels and the neutrophil-to-lymphocyte ratio, thereby mitigating inflammation. In conclusion, these findings suggest kombucha has potential anti-obesity and anti-inflammatory bioactivity for future health applications.