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Adjuvant effects of Lactobacillus on enhancing immune responses and anti2 influenza virus in mice

學生姓名: 蔡欣妤
指導教授: 吳彰哲
學期: 110上
摘  要: Influenza virus (IFV) is responsible of a highly contagious disease that has a substantial impact on global health. This virus is a major respiratory pathogen that causes a high degree of morbidity and mortality, especially in immunocompromised hosts. Natural components like probiotics have been severally studied and have been proved to be a safe alternative prophylactic and therapeutic approach for modulating immune responses via the induction of the newly described process of trained immunity. Lactobacillus is able to improve both the humoral and cellular adaptive immune responses induced by IFV infection or vaccination. Through the differential regulatory cytokines induced by Lactobacillus contributed to the protection against IFV without inducing inflammatory-mediated lung damage. Combining the above results, Lactobacillus can as a potential vaccine adjuvant, promoting the adjusting the pathways of innate and adaptive immunities through maintaining the balance between Th1 and Th2 lymphocytes in mice to enhancing protective efficacy of influenza vaccination.
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