Using oral or intranasal administration to study of the protective effects and mechanism of probiotics against influenza A virus infection
學生姓名:
蔡欣妤
指導教授:
吳彰哲
學期:
110下
摘 要:
Influenza virus (IFV) is responsible of a highly contagious disease that has a substantial impact on global health. This virus is a major respiratory pathogen that causes a high degree of morbidity and mortality, especially in immunocompromised hosts. Natural components like
probiotics have been severally studied and have been proved to be a safe alternative prophylactic. Probiotics may mediate their antiviral effects against respiratory viruses possibly by eliciting systemic immune responses via gut or enhancing cellular immunity with increased
activity of natural killer cells and macrophages; On the other hand, the intranasal administration of Lactobacillus had a protective effect on viral respiratory tract infections and enhancing the innate immune response in the respiratory mucosa. Therefore, the purpose of this study was that using oral or intranasal administration to study of the protective effects and mechanism of probiotics against influenza A virus infection. In vivo study, it was found that oral and Intranasal administration of Lactobacillus treatment stimulated adaptive immunities and induced Th1
cytokine production as well as diminishing the pro-inflammatory cytokines in the lung tissue to enhancing the mice survival rate. Combining the above results, these responses stimulated the pathways of adaptive immunities through increased the type1 helper T cell in mice and
exhibit both protective and prophylactic effects against inflienza A virus infection.
probiotics have been severally studied and have been proved to be a safe alternative prophylactic. Probiotics may mediate their antiviral effects against respiratory viruses possibly by eliciting systemic immune responses via gut or enhancing cellular immunity with increased
activity of natural killer cells and macrophages; On the other hand, the intranasal administration of Lactobacillus had a protective effect on viral respiratory tract infections and enhancing the innate immune response in the respiratory mucosa. Therefore, the purpose of this study was that using oral or intranasal administration to study of the protective effects and mechanism of probiotics against influenza A virus infection. In vivo study, it was found that oral and Intranasal administration of Lactobacillus treatment stimulated adaptive immunities and induced Th1
cytokine production as well as diminishing the pro-inflammatory cytokines in the lung tissue to enhancing the mice survival rate. Combining the above results, these responses stimulated the pathways of adaptive immunities through increased the type1 helper T cell in mice and
exhibit both protective and prophylactic effects against inflienza A virus infection.
專題討論摘要_20220511_蔡欣妤.pdf