臺灣博碩士論文加值系統

謝誌 I
摘要 II
Abstract III
縮寫表 IV
圖目次 X
表目次 XII
第一章 前言 1
第二章 文獻回顧 2
第一節 非酒精性脂肪肝及其相關疾病 2
1. 非酒精性脂肪肝疾病簡介 2
2. NAFLD 發展之多重撞擊假說 (multiple hit hypothesis) 2
3. 肝脂肪變性 3
4. 肝脂肪變性之成因 3
5. 非酒精性肝炎 3
第二節 NAFLD 診斷與治療 4
1. NAFLD 之判定 4
2. 非肥胖型 NAFLD 4
3. NAFLD治療方法 4
第三節 具肝毒性之脂質 5
1. 游離脂肪酸 5
2. 三酸甘油酯 6
第四節 脂質生合成及代謝相關因子 6
1. 脂質合成相關因子簡介 6
2. 脂質代謝相關因子簡介 7
第五節 NAFLD 與發炎 7
1. NAFLD 與 TNF-α 7
2. NAFLD 與介白素-1 (interleukin-1, IL-1) 家族 8
第六節 芝麻之生理活性 8
1. 芝麻簡介 8
2. 黑芝麻脂溶性萃取物 8
3. 抑癌能力 8
4. 神經保護能力 9
5. 降低心血管疾病風險 9
第七節 茶籽之生理活性 9
1. 茶籽簡介 9
2. 苦茶油 9
3. 抑癌 10
4. 抗發炎 10
5. 保肝 10
第八節 米糠及椰子油之生理活性 10
1. 米糠之生理活性 10
2. 椰子油之生理活性 11
第三章 研究設計 12
第四章 研究材料及方法 13
第一節 研究材料 13
1. 細胞株 13
2. 細胞培養用試劑及耗材 13
3. 藥品 13
4. 儀器設備 15
第二節 研究方法 16
1. 芝麻之一般成分分析 16
2. 植物油萃取及脂肪酸測定 17
3. 細胞實驗 19
第五章 結果 27
第一節 脂肪酸混合物 (FFA) 誘發肝細胞中性脂質累積 27
第二節 黑芝麻脂溶性萃取物及苦茶油減緩 FFA 誘導 TG 堆積 27
第三節 黑芝麻脂溶性萃取物、苦茶油活化 AMPK 28
第四節 黑芝麻脂溶性萃取物、苦茶油減緩FFA誘導之脂肪酸合成酶活性 28
第五節 黑芝麻脂溶性萃取物、苦茶油抑制轉錄因子 SREBP-1 28
第六節 黑芝麻脂溶性萃取物、苦茶油對FFA誘導細胞發炎之影響 29
第六章 討論 30
第一節 建立肝脂肪變性模式 30
1. NAFLD細胞模式 30
2. NAFLD動物模式 30
第二節 植物油對肝臟脂質累積的影響 31
第三節 黑芝麻脂溶性萃取物或苦茶油對肝細胞脂質生合成作用機制 31
第四節 苦茶油抑制肝細胞脂質累積之氧化壓力 32
第七章 結論 34
參考文獻 35

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