朱美嘉 (2012) Pseudomonas vesicularis MA103 Fucosidase 之 fucI基因轉殖至 Lactococcus lactis NZ3900 表現及Fucosidase rfucI-H水解岩藻聚醣所得寡醣於 Caco-2 細胞吸收效果之探討。國立臺灣海洋大學食品科學研究所碩士論文。基隆,臺灣。林雨欣 (2011) 蜆肉蛋白質水解物與龍鬚菜之組合物對降血膽固醇的效果。國立臺灣海洋大學食品科學研究所博士論文。基隆,臺灣。張劭強 (2013) 探討岩藻寡醣之最適生產條件與生理活性與經人類腸癌細胞株Caco-2吸收及運輸之變化。國立臺灣海洋大學食品科學研究所碩士論文。基隆,臺灣。陳宇潔 (2012) 利用Transwell 移動系統篩選高度移動能力之人類乳癌細胞之細胞特性與細胞移動機制。國立陽明大學藥理學研究所碩士論文。臺北,臺灣。陳國華 (2007) 蜆肉水解物膽酸結合與抗氧化能力的影響。國立臺灣海洋大學食品科學研究所碩士論文。基隆,臺灣。楊凱茜 (2012a) 蜜環菌乙素對人類胰臟癌PANC-1細胞之作用。國立臺灣海洋大學食品科學研究所碩士論文。基隆,臺灣。楊騏瑋 (2012b) 高硫酸基含量海藻寡醣之抗凝血與抗血小板凝集和抗病毒活性及被Caco-2細胞吸收效果之探討。國立臺灣海洋大學食品科學研究所碩士論文。基隆,臺灣。劉碧玉 (2012) 綠藻與蜆肉水解物降低高血糖的生理效果。國立臺灣海洋大學食品科學研究所碩士論文。基隆,臺灣。衛生福利部中央健康保險署 (2013) 全民健康保險藥品給付規定:第9章抗癌瘤藥物。臺北,臺灣。
衛生福利部國民健康署 (2005) 更年期荷爾蒙療法衛教手冊。臺北,臺灣。
衛生福利部國民健康署 (2014a) 2011年癌症登記報告。臺北,臺灣。
衛生福利部國民健康署 (2014b) 民國102年主要死因分析。臺北,臺灣。
蕭欣宜 (2008) 臺灣蜆 (Corbicula fluminea) 萃取物抗氧化成分之鑑定與一條根 (Glycine tomentella) 組合物對降血脂之影響。國立臺灣海洋大學食品科學研究所碩士論文。基隆,臺灣。謝岱霓 (2012) 阿魏酸引發人類乳癌MDA-MB-231細胞化療抗性、細胞遷移及HER2/ERα表現之影響。國立臺灣海洋大學食品科學研究所碩士論文。基隆,臺灣。Adams LS, Phung S, Yee N, Seeram NP, Li L, Chen S (2010) Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res 70: 3594-3605.
Alshatwi AA (2010) Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. J Exp Clin Cancer Res 29: 167.
American Cancer Society. Breast Cancer. Atlanta, Ga: American Cancer Society; 2014.
Arpino G, Wiechmann L, Osborne CK, Schiff R (2008) Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance. Endocr Rev 29: 217-233.
Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
Bradley CJ, Neumark D, Luo Z, Schenk M (2007) Employment and cancer: findings from a longitudinal study of breast and prostate cancer survivors. Cancer Invest 25: 47-54.
Chang CJ, Chiu JH, Tseng LM, Chang CH, Chien TM, Wu CW, Lui WY (2006) Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells. Eur J Clin Invest 36: 588-596.
Cho E, Spiegelman D, Hunter DJ, Chen WY, Stampfer MJ, Colditz GA, Willett WC (2003) Premenopausal fat intake and risk of breast cancer. J Natl Cancer Inst 95: 1079-1085.
Ciarlo L, Manganelli V, Garofalo T, Matarrese P, Tinari A, Misasi R, Malorni W, Sorice M (2010) Association of fission proteins with mitochondrial raft-like domains. Cell Death Differ 17: 1047-1058.
Cobleigh MA, Vogel CL, Tripathy D, Robert NJ, Scholl S, Fehrenbacher L, Wolter JM, Paton V, Shak S, Lieberman G, Slamon DJ (1999) Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 17: 2639-2648.
Cumashi A, Ushakova NA, Preobrazhenskaya ME, D'Incecco A, Piccoli A, Totani L, Tinari N, Morozevich GE, Berman AE, Bilan MI, Usov AI, Ustyuzhanina NE, Grachev AA, Sanderson CJ, Kelly M, Rabinovich GA, Iacobelli S, Nifantiev NE (2007) A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. Glycobiology 17: 541-552.
Dawood S (2010) Triple-negative breast cancer: epidemiology and management options. Drugs 70: 2247-2258.
Dieras V, Chevallier B, Kerbrat P, Krakowski I, Roche H, Misset JL, Lentz MA, Azli N, Murawsky M, Riva A, Pouillart P, Fumoleau P (1996) A multicentre phase II study of docetaxel 75 mg m-2 as first-line chemotherapy for patients with advanced breast cancer: report of the Clinical Screening Group of the EORTC. European Organization for Research and Treatment of Cancer. Br J Cancer 74: 650-656.
Ferreira AK, Meneguelo R, Pereira A, Filho OM, Chierice GO, Maria DA (2013) Synthetic phosphoethanolamine induces cell cycle arrest and apoptosis in human breast cancer MCF-7 cells through the mitochondrial pathway. Biomed Pharmacother 67: 481-487.
Filardo EJ, Quinn JA, Bland KI, Frackelton AR (2000) Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol 14: 1649-1660.
Fillmore CM, Kuperwasser C (2008) Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res 10: R25.
Gamcsik MP, Dubay GR, Cox BR (2002) Increased rate of glutathione synthesis from cystine in drug-resistant MCF-7 cells. Biochem Pharmacol 63: 843-851.
Geng Y, Chandrasekaran S, Hsu JW, Gidwani M, Hughes AD, King MR (2013) Phenotypic switch in blood: effects of pro-inflammatory cytokines on breast cancer cell aggregation and adhesion. PLoS One 8: e54959.
Gennari A, Sormani MP, Pronzato P, Puntoni M, Colozza M, Pfeffer U, Bruzzi P (2008) HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: a pooled analysis of randomized trials. J Natl Cancer Inst 100: 14-20.
Geyer CE, Forster J, Lindquist D, Chan S, Romieu CG, Pienkowski T, Jagiello-Gruszfeld A, Crown J, Chan A, Kaufman B, Skarlos D, Campone M, Davidson N, Berger M, Oliva C, Rubin SD, Stein S, Cameron D (2006) Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 355: 2733-2743.
Gnoth MJ, Rudloff S, Kunz C, Kinne RK (2001) Investigations of the in vitro transport of human milk oligosaccharides by a Caco-2 monolayer using a novel high performance liquid chromatography-mass spectrometry technique. J Biol Chem 276: 34363-34370.
Gurunathan S, Han JW, Eppakayala V, Jeyaraj M, Kim JH (2013) Cytotoxicity of biologically synthesized silver nanoparticles in MDA-MB-231 human breast cancer cells. Biomed Res Int 2013: 535796.
Hagiwara K, Kosaka N, Yoshioka Y, Takahashi RU, Takeshita F, Ochiya T (2012) Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity. Sci Rep 2: 314.
Hague A, Paraskeva C (2004) Apoptosis and disease: a matter of cell fate. Cell Death Differ 11: 1366-1372.
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144: 646-674.
Heinemann V (2005) Gemcitabine in metastatic breast cancer. Expert Rev Anticancer Ther 5: 429-443.
Henderson ES, Adamson RH, Oliverio VT (1965) The metabolic fate of tritiated methotrexate. II. Absorption and excretion in man. Cancer Res 25: 1018-1024.
Hirschmann-Jax C, Foster AE, Wulf GG, Nuchtern JG, Jax TW, Gobel U, Goodell MA, Brenner MK (2004) A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A 101: 14228-14233.
Howell A, Osborne CK, Morris C, Wakeling AE (2000) ICI 182,780 (Faslodex): development of a novel, "pure" antiestrogen. Cancer 89: 817-825.
Hsieh TC, Elangovan S, Wu JM (2010) Differential suppression of proliferation in MCF-7 and MDA-MB-231 breast cancer cells exposed to alpha-, gamma- and delta-tocotrienols is accompanied by altered expression of oxidative stress modulatory enzymes. Anticancer Res 30: 4169-4176.
Hwang-Verslues WW, Kuo WH, Chang PH, Pan CC, Wang HH, Tsai ST, Jeng YM, Shew JY, Kung JT, Chen CH, Lee EY, Chang KJ, Lee WH (2009) Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers. PLoS One 4: e8377.
Ivascu A, Kubbies M (2006) Rapid generation of single-tumor spheroids for high-throughput cell function and toxicity analysis. J Biomol Screen 11: 922-932.
Janmey PA, Miller RT (2011) Mechanisms of mechanical signaling in development and disease. J Cell Sci 124: 9-18.
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90.
Jenkins DE, Hornig YS, Oei Y, Dusich J, Purchio T (2005) Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice. Breast Cancer Res 7: R444-454.
Kim MY, Kim EJ, Kim YN, Choi C, Lee BH (2011) Effects of alpha-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats. Nutr Res Pract 5: 421-428.
Kinsella AR, Smith D, Pickard M (1997) Resistance to chemotherapeutic antimetabolites: a function of salvage pathway involvement and cellular response to DNA damage. Br J Cancer 75: 935-945.
Kok SH, Wong RS, Gambari R, Cheung F, Lam WS, Lau FY, Cheng GY, Cheng CH, Lam KH, Chan SH, Tang JC, Chui CH, Ho KP (2008) In vitro cytotoxicity of (-)-EGCG octaacetate on MDAMB-231 and SKHep-1 human carcinoma cells: a pharmacological consideration on prodrug design. Int J Mol Med 22: 841-845.
Konosu S, Watanabe K, Shimizu T (1974) Distribution of nitrogenous constituents in the muscle extracts of eight species of fish. Bull Japan Soc Sci Fish. 40: 909-915.
La Vecchia C, Decarli A, Franceschi S, Gentile A, Negri E, Parazzini F (1987) Dietary factors and the risk of breast cancer. Nutr Cancer 10: 205-214.
Lau D, Johl J, Huynh M, Davies A, Tanaka M, Lara P, Gandara D (2008) Population-based phase I trial of irinotecan and epirubicin. Am J Clin Oncol 31: 226-230.
Lee HJ, Paul S, Atalla N, Thomas PE, Lin X, Yang I, Buckley B, Lu G, Zheng X, Lou YR, Conney AH, Maehr H, Adorini L, Uskokovic M, Suh N (2008) Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicity. Cancer Prev Res (Phila) 1: 476-484.
Lee HJ, So JY, DeCastro A, Smolarek A, Paul S, Maehr H, Uskokovic M, Suh N (2010) Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling. J Steroid Biochem Mol Biol 121: 408-412.
Lee JH, Li YC, Ip SW, Hsu SC, Chang NW, Tang NY, Yu CS, Chou ST, Lin SS, Lino CC, Yang JS, Chung JG (2008) The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway. Anticancer Res 28: 1701-1711.
Li B, Lu F, Wei X, Zhao R (2008) Fucoidan: structure and bioactivity. Molecules 13: 1671-1695.
Liao N, Chen S, Ye X, Zhong J, Wu N, Dong S, Yang B, Liu D (2013) Antioxidant and anti-tumor activity of a polysaccharide from freshwater clam, Corbicula fluminea. Food Funct 4: 539-548.
Liedtke C, Mazouni C, Hess KR, Andre F, Tordai A, Mejia JA, Symmans WF, Gonzalez-Angulo AM, Hennessy B, Green M, Cristofanilli M, Hortobagyi GN, Pusztai L (2008) Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol 26: 1275-1281.
Lin L, Hutzen B, Lee HF, Peng Z, Wang W, Zhao C, Lin HJ, Sun D, Li PK, Li C, Korkaya H, Wicha MS, Lin J (2013) Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells. PLoS One 8: e82821.
Lin W, Zhao J, Cao Z, Zhuang Q, Zheng L, Cai Q, Chen D, Wang L, Hong Z, Peng J (2013) Livistona chinensis seed suppresses hepatocellular carcinoma growth through promotion of mitochondrial-dependent apoptosis. Oncol Rep 29: 1859-1866.
Lind DS (2004) Arginine and cancer. J Nutr 134: 2837-2841.
Liu K, Cang S, Ma Y, Chiao JW (2013) Synergistic effect of paclitaxel and epigenetic agent phenethyl isothiocyanate on growth inhibition, cell cycle arrest and apoptosis in breast cancer cells. Cancer Cell Int 13: 10.
Matsuyoshi S, Shimada K, Nakamura M, Ishida E, Konishi N (2006) FADD phosphorylation is critical for cell cycle regulation in breast cancer cells. Br J Cancer 94: 532-539.
Mercer RR, Mastro AM (2005) Cytokines secreted by bone-metastatic breast cancer cells alter the expression pattern of f-actin and reduce focal adhesion plaques in osteoblasts through PI3K. Exp Cell Res 310: 270-281.
Morini M, Mottolese M, Ferrari N, Ghiorzo F, Buglioni S, Mortarini R, Noonan DM, Natali PG, Albini A (2000) The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity. Int J Cancer 87: 336-342.
Morrison J, Briggs SS, Green N, Fisher K, Subr V, Ulbrich K, Kehoe S, Seymour LW (2008) Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor. Mol Ther 16: 244-251.
Mueller C, Emmrich J, Jaster R, Braun D, Liebe S, Sparmann G (2006) Cis-hydroxyproline-induced inhibition of pancreatic cancer cell growth is mediated by endoplasmic reticulum stress. World J Gastroenterol 12: 1569-1576.
Murphy G, Nagase H (2011) Localizing matrix metalloproteinase activities in the pericellular environment. FEBS J 278: 2-15.
Nakanishi T, Chumsri S, Khakpour N, Brodie AH, Leyland-Jones B, Hamburger AW, Ross DD, Burger AM (2010) Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling. Br J Cancer 102: 815-826.
Nakshatri H, Srour EF, Badve S (2009) Breast cancer stem cells and intrinsic subtypes: controversies rage on. Curr Stem Cell Res Ther 4: 50-60.
NCCN - National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology™. Breast Cancer V.3; 2014. http://www.nccn.org. (assessed 13, Aug, 2014)
Phillips TM, McBride WH, Pajonk F (2006) The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst 98: 1777-1785.
Plumb JA, Milroy R, Kaye SB (1989) Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay. Cancer Res 49: 4435-4440.
Rajput S, Volk-Draper LD, Ran S (2013) TLR4 is a novel determinant of the response to paclitaxel in breast cancer. Mol Cancer Ther 12: 1676-1687.
Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414: 105-111.
Sahni S, Zoltick ES, McLean RR, Hannan MT (2010) Non-D vitamins and bone health in adults. IBMS 7: 431-446.
So JY, Lee HJ, Smolarek AK, Paul S, Wang CX, Maehr H, Uskokovic M, Zheng X, Conney AH, Cai L, Liu F, Suh N (2011) A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer. Mol Pharmacol 79: 360-367.
Sparano JA, Wang M, Martino S, Jones V, Perez EA, Saphner T, Wolff AC, Sledge GW, Jr., Wood WC, Davidson NE (2008) Weekly paclitaxel in the adjuvant treatment of breast cancer. N Engl J Med 358: 1663-1671.
Taherian A, Mazoochi T (2012) Different Expression of Extracellular Signal-Regulated Kinases (ERK) 1/2 and Phospho-Erk Proteins in MBA-MB-231 and MCF-7 Cells after Chemotherapy with Doxorubicin or Docetaxel. Iran J Basic Med Sci 15: 669-677.
Tamaki H, Satoh H, Hori S, Ohtani H, Sawada Y (2010) Inhibitory effects of herbal extracts on breast cancer resistance protein (BCRP) and structure-inhibitory potency relationship of isoflavonoids. Drug Metab Pharmacokinet 25: 170-179.
Traverso N, Ricciarelli R, Nitti M, Marengo B, Furfaro AL, Pronzato MA, Marinari UM, Domenicotti C (2013) Role of glutathione in cancer progression and chemoresistance. Oxid Med Cell Longev 2013: 972913.
Tsai J, Lin T, Chen J, Pan B (2006) The inhibitory effects of freshwater clam (Corbicula fluminea, Muller) muscle protein hydrolysates on angiotensin I converting enzyme. Process Biochemistry 41: 2276-2281.
Turner NA, O'Regan DJ, Ball SG, Porter KE (2005) Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels. FASEB J 19: 804-806.
Urakami M, Ano R, Kimura Y, Shima M, Matsuno R, Ueno T, Akamatsu M (2003) Relationship between structure and permeability of tryptophan derivatives across human intestinal epithelial (Caco-2) cells. Z Naturforsch C 58: 135-142.
van Roeyen CR, Ostendorf T, Floege J (2012) The platelet-derived growth factor system in renal disease: an emerging role of endogenous inhibitors. Eur J Cell Biol 91: 542-551.
Wang L, Ling Y, Chen Y, Li CL, Feng F, You QD, Lu N, Guo QL (2010) Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells. Cancer Lett 297: 42-48.
Wang PH, Shyong WY, Li YF, Lee HH, Tsai WY, Chao HT, Wu CY, Tsai YC, Yuan CC (2000) BRCA1 mutations in Taiwanese with epithelial ovarian carcinoma and sporadic primary serous peritoneal carcinoma. Jpn J Clin Oncol 30: 343-348.
Wang Z, Ahmad A, Li Y, Kong D, Azmi AS, Banerjee S, Sarkar FH (2010) Emerging roles of PDGF-D signaling pathway in tumor development and progression. Biochim Biophys Acta 1806: 122-130.
Weerachayaphorn J, Pajor AM (2008) Identification of transport pathways for citric acid cycle intermediates in the human colon carcinoma cell line, Caco-2. Biochim Biophys Acta 1778: 1051-1059.
Yaacob NS, Nengsih A, Norazmi MN (2013) Tualang honey promotes apoptotic cell death induced by tamoxifen in breast cancer cell lines. Evid Based Complement Alternat Med 2013: 989841.
Yadav S, Sehrawat A, Eroglu Z, Somlo G, Hickey R, Yadav S, Liu X, Awasthi YC, Awasthi S (2013) Role of SMC1 in overcoming drug resistance in triple negative breast cancer. PLoS One 8: e64338.
Young SD, Whissell M, Noble JC, Cano PO, Lopez PG, Germond CJ (2006) Phase II clinical trial results involving treatment with low-dose daily oral cyclophosphamide, weekly vinblastine, and rofecoxib in patients with advanced solid tumors. Clin Cancer Res 12: 3092-3098.
Zhang J, Cao R, Zhang Y, Jia T, Cao Y, Wahlberg E (2009) Differential roles of PDGFR-alpha and PDGFR-beta in angiogenesis and vessel stability. FASEB J 23: 153-163.
Zhang X, Min J, Wang Y, Li Y, Li H, Liu Q, Liang X, Mu P, Li H (2013) RABEX-5 plays an oncogenic role in breast cancer by activating MMP-9 pathway. J Exp Clin Cancer Res 32: 52.
Zhang Z, Teruya K, Eto H, Shirahata S (2011) Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ROS-dependent JNK activation and mitochondria-mediated pathways. PLoS One 6: e27441.
Zhang Z, Teruya K, Eto H, Shirahata S (2013) Induction of apoptosis by low-molecular-weight fucoidan through calcium- and caspase-dependent mitochondrial pathways in MDA-MB-231 breast cancer cells. Biosci Biotechnol Biochem 77: 235-242.
Zheng Y, Scow JS, Duenes JA, Sarr MG (2012) Mechanisms of glucose uptake in intestinal cell lines: role of GLUT2. Surgery 151: 13-25.