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Investigating the Effects of Alpha-Linolenic Acid on Allergic Rhinitis in Mice

學生姓名: 洪詩喩
指導教授: 黃崇雄
學期: 113上
摘  要: Allergic rhinitis is one of the most common chronic non-infectious diseases, affecting approximately 10-40% of the global population. Common symptoms include sneezing, nasal itching, and a runny nose. While antihistamines and steroids are frequently prescribed for treatment, long-term use of these medications may lead to adverse side effects. Consequently, there is growing interest in developing alternative therapies to address the limitations of conventional treatments.Alpha-linolenic acid (ALA), an omega-3 polyunsaturated fatty acid, has demonstrated anti-inflammatory properties in previous studies, indicating its potential as a novel therapeutic strategy for allergic diseases. This study investigates the effects of ALA and ALA derived from flaxseed oil on upper respiratory allergic rhinitis. The literature suggests that ALA significantly reduced nasal mucosal inflammation and alleviated allergic symptoms. Further research reveals that ALA exerted its effects by inhibiting the IL-4Rα-JAK2-STAT3 signaling pathway, reducing Th2 cell activation, and suppressing the release of related inflammatory mediators, thus improving nasal mucosal barrier function. Additionally, ALA from flaxseed oil could diminish allergic responses by locally producing 15-HEPE through eosinophil infiltration in the nasal cavity. 15-HEPE inhibited mast cell degranulation in a PPARγ-dependent manner, further suppressing allergic reactions.In summary, ALA and ALA derived from flaxseed oil attenuate OVA-induced allergic rhinitis by modulating various physiological responses, highlighting ALA's potential as a novel therapeutic strategy for allergic rhinitis.
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