Quantitative Proteomic Analysis of Antibacterial Mechanism of linalool
學生姓名:
曾昱凱
指導教授:
陳泰源
學期:
113上
摘 要:
Linalool is an acyclic monoterpene tertiary alcohol and also one of the major floral scents in nature. It has been applied to a variety of products including body lotions, shampoos, shower gels, soaps, hairsprays, creams and beverages. In spite of being as fragrance and flavoring agent, it also exhibits great antibacterial ability by inhibiting the synthesis of pathways related to obtaining energy. In order to figure out how bacteria response after linalool’s treatment, in this report, both article utilized proteomics technology investigate the differentially expressed
protein (DEPs) to speculate the antibacterial mec hanism of linalool. In the proteomics analysis of Listeria monocytogenes treated with linalool, Gene Ontology (GO) and Kyoto Encyclopedia of Genes (KEGG) databases were used to annotate and analyze the functions of the identified proteins to explore their biological pathways and functions; both database indicated that ribosome were significantly influenced by linalool, another report from Shigella sonnei treated with linalool also had similar result, although ribosome associated protein significantly up regulated, the limitation of specific amino acid may acted as a negative feedback regulation signal to stimulate ribosome expression.
protein (DEPs) to speculate the antibacterial mec hanism of linalool. In the proteomics analysis of Listeria monocytogenes treated with linalool, Gene Ontology (GO) and Kyoto Encyclopedia of Genes (KEGG) databases were used to annotate and analyze the functions of the identified proteins to explore their biological pathways and functions; both database indicated that ribosome were significantly influenced by linalool, another report from Shigella sonnei treated with linalool also had similar result, although ribosome associated protein significantly up regulated, the limitation of specific amino acid may acted as a negative feedback regulation signal to stimulate ribosome expression.