Exploring the Potential of Probiotics with Fat-Reducing Properties in Geroprotective and Antioxidant Mechanisms Using Caenorhabditis elegans
學生姓名:
周立翔
指導教授:
陳詠宗
學 期:
113下
摘 要:
Aging-related health decline and gut microbiota imbalance have driven interest in probiotics as potential geroprotectors. This study integrates findings from two investigations on probiotic-mediated longevity in C. elegans. B. animalis subsp. lactis BPL1™ and its derivatives (BPL1™ HT, LTA) extend lifespan via the IGF-1 pathway, improving oxidative stress resistance, gut integrity, and neuroprotection. Notably, BPL1™ does not involve p38 MAPK or JNK-1/DAF-16 pathways, confirming IGF-1 as its primary metabolic target for lifespan extension and fat reduction.In contrast, L. brevis and W. coagulans extend lifespan through IIS and p38 MAPK pathways, enhancing gut barrier function and stress resistance. W. coagulans longevity effects depend on sir-2.1, jnk-1, nuo-6, and isp-1, implicating JNK pathways, and mitochondrial function in aging regulation. Additionally, both strains reduce age-related ectopic fat accumulation via NHR-49, a key lipid metabolism regulator.These findings highlight distinct probiotic mechanisms in aging regulation: BPL1™ acts via IGF-1, while L. brevis and W. coagulans utilize IIS, p38 MAPK, and mitochondrial pathways. Given the conservation of these mechanisms across species, further studies in higher organisms are needed to explore their potential for promoting human longevity.
周立翔.pdf