Regulatory Effects of Extra Virgin Olive Oil Polyphenols on Metabolism and Signaling Pathways in Breast Cancer Cells
學生姓名:
陳巧臻
指導教授:
張君如
學 期:
113下
摘 要:
Extra-virgin olive oil (EVOO) contains bioactive polyphenols, such as oleuropein and its hydrolysis products, which have demonstrated anticancer potential. Breast cancer cells exhibit metabolic adaptations, including altered glucose and glutamine metabolism, enabling survival and proliferation. This report investigated the effects of EVOO and its key components on breast cancer metabolism and signaling pathways. EVOO was found to inhibit the PI3K/AKT signaling pathway, reducing cancer cell proliferation and survival. It also modulated energy metabolism by enhancing the TCA cycle and oxidative phosphorylation (OXPHOS) while downregulating glutaminase (GLS), limiting glutamine utilization. Additionally, EVOO increased reactive oxygen species (ROS) accumulation, induced oxidative stress and triggered apoptosis via cytochrome c release and caspase activation. These findings suggest that EVOO polyphenols suppress tumor growth by disrupting metabolic and survival pathways. These studies support EVOO as a potential adjuvant therapy for breast cancer. Future research should explore its role across different breast cancer subtypes and its combination with standard treatments to develop more effective therapeutic strategies.
陳巧臻.pdf