Investigating the potential of phenolic and diterpenoid compounds as efflux pump inhibitors: targeting the reduction of antibiotic resistance and biofilm formation in multidrug-resistant pathogens
學生姓名:
江立荷
指導教授:
林泓廷
學 期:
113下
摘 要:
Antimicrobial resistance (AMR) is a major global health challenge, with bacterial efflux pump overexpression contributing to multidrug resistance and extensively drugresistant (XDR) strains. This report explores plant-derived secondary metabolites as potential efflux pump inhibitors (EPIs). Chlorogenic acid and carnosol reduced the minimum inhibitory concentration (MIC) of XDR Staphylococcus aureus and Pseudomonas aeruginosa, inhibited efflux pump activity, and suppressed biofilm formation, especially in XDR P. aeruginosa, with minimal cytotoxicity. demonstrated that resveratrol inhibited the S. aureus NorA efflux pump, lowered norfloxacin MIC, increased ethidium bromide accumulation, and reduced resistance mutation frequency while prolonging the post-antibiotic effect. These findings suggest that plant-derived metabolites enhance antibiotic efficacy and could serve as potential therapeutic agents against AMR.
江立荷.pdf