Metal Salts and Metal Complexes as Promising Efflux Pump Inhibitors to Combat Multidrug-Resistant Bacteria
學生姓名:
江立荷
指導教授:
林泓廷
學 期:
114上
摘 要:
The rapid emergence of multidrug-resistant (MDR) bacteria poses a major challenge to clinical treatment, largely driven by efflux pump overexpression and biofilm formation. Metal salts and complexes have recently gained attention as novel antibacterial strategies. Zinc sulfate demonstrated strong efflux pump inhibition against Pseudomonas aeruginosa clinical isolates, reducing MDR phenotypes even at sub-inhibitory concentrations and showing synergism with multiple antibiotics. Likewise, α-picolinic acid-derived palladium (II) complexes, especially QSL_Pd5A, inhibited the NorA efflux pump in Staphylococcus aureus, disrupted biofilm formation, and enhanced fluoroquinolone activity. Notably, QSL_Pd5A retained potency at low concentrations without significant cytotoxicity, while molecular docking confirmed its high affinity for the NorA protein through extensive hydrophobic interactions. Collectively, these findings underscore the promise of metal salts and palladium complexes in sensitizing resistant pathogens to antibiotics and suppressing resistance mechanisms, offering a potential foundation for next-generation antimicrobial development.
專題討論0917-江立荷-摘要.pdf