Ameliorative Effects of Plant-Derived Extracellular Vesicles on Intestinal
學生姓名:
蔡佳妤
指導教授:
吳彰哲
學 期:
114上
摘 要:
Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are major intestinal disorders, yet current therapies often cause adverse effects and show limited efficacy, highlighting the need for novel adjunctive strategies. This study investigated the therapeutic potential of plant-derived extracellular vesicles (EVs) in intestinal diseases. Garlic-derived EVs (GELNs), enriched with peu-MIR2916-p3, were found to modulate gut microbiota, particularly by promoting the growth of Bacteroides thetaiotaomicron, thereby alleviating DSS-induced colitis and restoring intestinal barrier function in mice. Meanwhile, EVs derived from Raphanus sativus L. var. caudatus Alef, characterized by β-sheet-rich macromolecular proteins, induced DNA damage and apoptosis in HCT116 colorectal cancer cells while exhibiting lower cytotoxicity toward normal cells compared with cisplatin. Collectively, these findings suggest that plant-derived EVs possess significant potential as complementary
therapeutic strategies for IBD and CRC, offering novel avenues for clinical applications.
therapeutic strategies for IBD and CRC, offering novel avenues for clinical applications.
蔡佳妤.pdf