Phytochemicals inhibit atopic dermatitis by modulating pro2 inflammatory cytokines
學生姓名:
莊凱恩
指導教授:
吳彰哲
學期:
111下
摘 要:
Atopic dermatitis is an allergic dermatosis that occurs in young children between the ages of one and two years, in people with congenital genetic defects, and in people with immune system disorders. The cause of Atopic dermatitis is the entry of allergens into the body through the defective skin barrier, which leads to the differentiation of excessive Th2 helper T cells (Th2), and the release of cytokines (IL-4, IL-13, etc.) from Th2 that trigger acute and chronic allergic reactions. dermatitis. Phytochemicals refer to natural chemicals found in plants, usually those that may affect human health, but can also refer to essential nutrients. Phytochemicals can be broadly classified as glycans, lipids, terpenoids, phenols, and alkaloids, which are mainly known for their metabolic, anticancer, antibacterial, neuropathy inhibition, oral health maintenance, and wound healing effects. In some studies, the anti-inflammatory effect of phytochemicals can affect the balance between TH1 and TH2 of the body's acquired immunity, which can be restored by suppressing Th2 or increasing the differentiation of Th1 through ingestion and patching, thus achieving the effect of slowing down atopic dermatitis. Among the phytochemicals selected in this study, Tea saponin belongs to the glycoside group, while Sophoricoside and Galangin belong to the phenolic group of phytochemicals. Sophoricoside has been detected to inhibit the differentiation of CD4+ T cells into other helper T cells, which can become a preventive agent of inflammation.
莊凱恩_11132032_2023.03.08_書面摘要.pdf