Adverse Effects of Reproductive Toxicity and Metabolism in Mice by Polystyrene Microplastics
學生姓名:
許瑜真
指導教授:
龔瑞林
學期:
111下
摘 要:
Microplastics (MPs) are plastic particles with a size of less than 5 mm and are derived from any kind of plastic. Humans may be exposed to MPs by ingesting contaminated food and water, and MPs may infiltrate and accumulate in human tissues, posing a health risk. However, research on the toxic effects of MPs on the reproductive system on mammals is relatively limited as well as health hazards associated with pristine and ultraviolet-aged MPs remain largely unknown. Therefore, this study evaluated the reproductive toxicity and changes in toxicity of pristine and aged MPs to different organs in mice. Both MPs and aged MPs caused structural damage to the mouse gut, liver, spleen, and testis. MPs may cause damage to mouse sperm production through testicular injury, which in turn leads to a decrease in sperm quality. Increases in serum alanine aminotransferase and immunoglobulin A levels in 1 mg/day aged MPs group demonstrated that aged MPs exposure could induce greater liver and spleen functional damage than PS. Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) levels in the MPs and aged MPs groups showed significant increases in the liver and testis, and a significant decrease in the spleen, which were analyzed to get a first survey for Nrf2/HO-1-mediated tissue-specific defense mechanisms. In conclusion, exposure to MP and aged MPs induced potential metabolic disorders, and aged MPs could produce more serious immune damage and reproductive toxicity.
1112專題討論摘要_許瑜真.pdf