To Investigate the Impact of Extracts from Nigella sativa on Skin Aging and Melanogenesis
學生姓名:
劉芳伶
指導教授:
黃崇雄
學 期:
112上
摘 要:
Black cumin (Nigella sativa L.) extract contains bioactive compounds like thymoquinone (TQ) and its derivatives, known for their antioxidative and antiinflammatory properties. Thymocid® , a commercially standardized black cumin extract, offers potential skin benefits. Ultraviolet A (UVA) can lead to skin oxidative damage, apoptosis, photoaging, and pigmentation. This report explores the skin-protective potential of black cumin extract, suggesting its application in skincare and addressing various skin concerns. These studies have highlighted the pivotal role of black cumin extract, particularly TQ in shielding skin cells against the detrimental effects of oxidative stress and external factors, primarily through the Nrf2/ARE pathway. TQ's action initiated this pathway, resulting in the activation of superoxide dismutase (SOD) and heme oxygenase-1 (HO-1), which collectively counteract oxidative damage, inflammation, and mitochondrial dysfunction. Notably, TQ has demonstrated a remarkable capacity to enhance cell viability when exposed to UVA radiation, a significant contributor to skin damage. Thymocid® , the source of this extract, was found to contain approximately 5.12% TQ, making it an effective inhibitor of the formation of advanced glycation end products (AGEs) and collagen cross-linking. These processes are central to the aging of the skin. Furthermore, Thymocid® effectively reduced the activity of collagenase and elastase, contributing significantly to the maintenance of skin elasticity. Additionally, Thymocid® exhibits noteworthy inhibitory effects on tyrosinase. This property results in a substantial reduction in melanin synthesis within melanoma cells, accompanied by the downregulation of melanogenesis-related genes and proteins. These collective findings highlight the Thymocid® 's multifaceted benefits in promoting skin health and combating various aspects of skin aging. In summary, the primary active compound in black cumin seed extract is TQ, known for its skin-protective properties, including anti-photoaging, anti-skin aging, and melanin inhibition.
1121-abst-劉芳伶.pdf