Red Ginseng and Prunus mira Koehne Oil: Hair Regrowth via Wnt/β-catenin Pathway
學生姓名:
張瑜珊
指導教授:
龔瑞林
學期:
112下
摘 要:
Hair loss is a dermatological condition characterized by the loss of hair, which has a noticeable impact on one's physical appearance. The etiology of this condition is commonly attributed to factors such as heredity, immune regulation, hormone levels, mental and psychological factors, and nutritional status. Previous research has also shown that there is a correlation between the Wnt/β-catenin pathway and hair regeneration. Therefore, It is worth investigating the potential of manipulating the Wnt/β-catenin pathway to achieve hair regeneration. The choice of plants as the focus of this study was based on previous research indicating that plant oils can stimulate hair growth and enhance skin health. Red ginseng and Prunus mira Koehne are rich in linoleic acid, which can effectively control the expression of proteins in the Wnt/β-catenin pathway, thus hypothesizing that it could stimulate hair growth. Studies have shown that research on Both researches use mice for experiments. RGO use C57BL/6 and SKH-1 hairless mice for animal experiments. Another study use C57BL/6 and KM mice , rabbits for experiments. RGO can enhance the protein expression of β-catenin, p-GSK3β, and lymphoid enhancer-binding factor 1 (Lef-1) compared to the control group. Additionally, RGO can upregulate genes related to hair growth in mouse skin tissue and is formulated to stimulate hair follicle regeneration and enhance hair growth. On the other hand, Prunus mira Koehne oil divided into different concentrations. When applied at a
concentration of 30.13 mg (cm2 d)-1 has a significant effect on increasing the hair weight and follicle number. On the other hand, has an outstanding effect on increasing the expression of Wnt10b, β-catenin and GSK-3β of mRNA and protein. These researches findings demonstrate that RGO and Prunus mira Koehne oin can promote hair regrowth by modulating the expression of β-catenin, Wnt10b and GSK-3β in the Wnt/β-catenin pathway.
concentration of 30.13 mg (cm2 d)-1 has a significant effect on increasing the hair weight and follicle number. On the other hand, has an outstanding effect on increasing the expression of Wnt10b, β-catenin and GSK-3β of mRNA and protein. These researches findings demonstrate that RGO and Prunus mira Koehne oin can promote hair regrowth by modulating the expression of β-catenin, Wnt10b and GSK-3β in the Wnt/β-catenin pathway.
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