Investigating the regulatory effect of omega-3 polyunsaturated fatty acid 2 supplementation on the immune imbalance induced by crystalline silica (cSiO₂) in mice
學生姓名:
蔡翊菻
指導教授:
黃崇雄
學 期:
114上
摘 要:
Systemic lupus erythematosus (SLE) is an autoimmune disease mediated by autoantibodies (AAb), characterized by disruption of immune tolerance and overactivation of B cells, leading to damage to organs. Recent studies have pointed out that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in omega-3 polyunsaturated fatty acids (PUFAs), may have a regulatory effect on immune imbalance. In the first study, the authors used cSiO2- induced NZBWF1 mice to simulate the onset of autoimmune diseases. The results showed that DHA intervention can inhibit the production of inflammatory cytokines and regulate the differentiation of B cells, and reduce the production of AAbs, indicating that omega-3 can delay the course of lupus. The second study focused on the acute pulmonary immune response after cSiO₂ exposure. High-dose DHA can effectively intervention inhibit the elevation of antibodies and downgrade the antigen presentation of inflammation-related pathways, thereby reducing lung inflammation and immune imbalance. Combining the two studies, the protective effect of omega-3 is mainly by inhibit B cell differentiation and AAbs production, as well as control antigen-presenting cells (APCs) activation and inflammatory gene expression. These results show that omega-3 has potential nutritional adjuvant therapeutic value for autoimmune diseases.
蔡翊菻.pdf