Docosahexaenoic Acid Ameliorates Inflammation and Prevent Obesity-Related Insulin Resistance via EP4 receptor
學生姓名:
王杰鴻
指導教授:
龔瑞林
學 號:
10432005
學期:
104上
摘 要:
In past few years, the development rate of obesity had been increasing in a constant rate. Obesity is known as one of the causes of many systemic and metabolic diseases. It is related to the development of Insulin Resistance which may lead to Type II Diabetes Mellitus. The main cause of the development of Insulin Resistance is chronic inflammation promoted by obese adipose tissue, which contains pro-inflammatory macrophages. As the adipose tissue grow, it releases cytokines and chemokines which recruit macrophages to infiltrate into adipose tissue and polarized into pro-inflammatory types of macrophages via induction of inflammatory cytokines.
DHA, Docosahexaenoic Acid, is one of n-3 polyunsaturated fatty acids which can be found in fish oils. It has been studied and shown to have benefits on human body, which one of its benefits is the amelioration of inflammation. The signaling pathway of DHA to anti-inflammatory effect is complicated, but it is certainly involved the production of eicosanoids. These eicosanoids are said to be interact with one of their receptors, EP4, which then activate the anti-inflammatory signaling cascades.
Present study uses DHA to observe the effect on obesity-induced inflammation and the anti-inflammatory responses by macrophages. We found that n-3 PUFA may decrease adipose tissue inflammation in dose dependent manner. We also figured out one of the possible pathway in DHA ameliorating inflammation is through the activation of EP4 receptor. This pathway might able to ameliorate insulin resistance in Type II Diabetes Mellitus.
DHA, Docosahexaenoic Acid, is one of n-3 polyunsaturated fatty acids which can be found in fish oils. It has been studied and shown to have benefits on human body, which one of its benefits is the amelioration of inflammation. The signaling pathway of DHA to anti-inflammatory effect is complicated, but it is certainly involved the production of eicosanoids. These eicosanoids are said to be interact with one of their receptors, EP4, which then activate the anti-inflammatory signaling cascades.
Present study uses DHA to observe the effect on obesity-induced inflammation and the anti-inflammatory responses by macrophages. We found that n-3 PUFA may decrease adipose tissue inflammation in dose dependent manner. We also figured out one of the possible pathway in DHA ameliorating inflammation is through the activation of EP4 receptor. This pathway might able to ameliorate insulin resistance in Type II Diabetes Mellitus.
10432005-1-王杰鴻-龔瑞林.pdf