Investigation of chitosan-graphene oxide nanocomposites for medicine application
學生姓名:
潘承昕
指導教授:
黃意真
學 號:
10332030
學期:
103下
摘 要:
In this work, prepared graphene oxide (GO) via chemical oxidation method using graphite powder and graphite flakes as starting materials to generate a small area GO (sGO) and a large area GO (hGO). The sGO and hGO were reduced by sodium hydroxide, in which the reduced GO (rGO) with small area and large area. Glass transition temperature (Tg) and mechanical strength of GO and rGO at concentrations of 0.3%, 0.6% and 0.9% they found that the former displayed superior thermal and tensile properties in chitosan-graphene films. By increasing the GO content from 0% to 6%, the strength and elastic modulus of the layers increased. The chitosan-GO composite layers showed significant antibacterial activity against Staphylococcus aureus bacteria. The actin cytoskeleton fibers of human mesenchymal stem cells (hMSCs) cultured on the chitosan and chitosan-GO (1.5%) composite layers was found nearly the same, while it significantly decreased by increasing the GO content to 3% and 6%. The chitosan-GO nanocomposite with 2% GO provided the optimal combination of mechanical properties and drug-loading capacity. The drug delivery profiles of the nanocomposite were dependent on the drug loading ratio, with 0.84:1 being the best ratio of drug to GO for a quick and high release of the loaded drug. The nanocomposite also demonstrated pH sensitivity of drug release, releasing 48% less drug in an acidic condition than in a neutral environment.
10332030-2-潘承昕-黃意真.pdf