(提供全額獎學金)

領　　域：酵素方法合成醣蛋白和多醣

地　　點：瑞典斯德哥爾摩皇家理工學院(KTH) 工程學院化學系醣生物學組 謝尚逸教授實驗室

必備資格：

• 有機化學碩士或相關系所畢業
• 良好英語溝通及讀寫能力
• 具正確學術倫理認知與態度
• 具創新思維

待　　遇：

• 比照KTH員工福利，享有瑞典政府醫療保險並可申請學生宿舍
• 薪資(即獎學金)比照KTH博士生，第一年每月29,000瑞典克朗(SEK)，每 年調薪，第四年每月34,000瑞典克朗(SEK)， 調薪比例依KTH規定如下 : https://intra.kth.se/en/anstallning/anstallningsvillkor/lon/doktorandstegen-1.572915

如需要更多資訊  請逕聯絡謝尚逸教授email: yvhsieh@kth.se

申請時間：14/June/2018  至 31/Aug/2018

研究課題：

It is well known today that over 50% of modern drugs target membrane proteins. The bottleneck in biochemical study of such proteins is the structural diversity  of  post-translational modifications, particularly the glycosylation. The glycoprotein most often exists as glycoforms; proteins that differ only with respect to the number and/or type of attached carbohydrate moieties. Therefore, considerable effort has been invested in determining the precise biological roles of structurally defined glycoproteins and, as such, has now emerged as an important area of post-genomic research. The chemical synthesis provides a unique tool to produce the homogeneous glycoprotein. Despite their value, only small number of glycoprotein have been synthesized, and none of these are membrane-bounded protein. Herein, the project aimed to combine Fmoc-SPPS, recombinant protein expression technologies, peptide ligation chemistries, chemoenzymatic glycan transfer and protein folding, for the practical production of homogeneous membrane glycoproteins. Synthetic products will be assembled in nano-disc, which enables the importance of the carbohydrate moieties for the structure and function of a membrane protein to be interrogated for the first time.The successful candidate will undertake a multi-disciplinary approach to complete the task and will be supervised by Assistant Professor Yves Hsieh. Majority of laboratory  work  will  be carried out in the Division of Glycosciences, at the Dept of Chemistry. There is also a possibility to visit and work at our collaborator’s laboratories within the CBH School at Dept of Biomedical Engineering and Health Systems, or Academia Sinica and KI.