Antioxidant activity of purified ulvan in hyperlipidemic mice
學生姓名:
李玗庭
學期:
107下
摘 要:
Several studies have reported that ulvan from the alga Ulva pertusa (Chlorophyta)
exhibits substantial antioxidant and antihyperlipidemic activities; however, which
group of heteropolysaccharides play roles in these activities remains unknown. In this
study, three purified ulvan (PU1, PU2 and PU3) have been obtained by DEAESepharose
fast-flow column. The antioxidant activity was detected via the model of
hyperlipidemic Kunming mice, including malondialdehyde (MDA), superoxide
dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in liver. PU3,
which possessed the highest uronic acid content (24.09%) and sulfate content (23.99%)
as well as the lowest average molecular weight (83094Da), exhibited the stronger
antioxidant activity than other examples. It significantly decreased MDA (29.2%; P <
0.05), increased SOD (36.4%; P < 0.05) and CAT (43.6%; P < 0.05) compared with
hyperlipidemia group. In conclusion, PU3 may be potential sources of natural
antioxidant to protecting against the liver damage of oxidative stress induced by
cholesterol-rich diet.
exhibits substantial antioxidant and antihyperlipidemic activities; however, which
group of heteropolysaccharides play roles in these activities remains unknown. In this
study, three purified ulvan (PU1, PU2 and PU3) have been obtained by DEAESepharose
fast-flow column. The antioxidant activity was detected via the model of
hyperlipidemic Kunming mice, including malondialdehyde (MDA), superoxide
dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in liver. PU3,
which possessed the highest uronic acid content (24.09%) and sulfate content (23.99%)
as well as the lowest average molecular weight (83094Da), exhibited the stronger
antioxidant activity than other examples. It significantly decreased MDA (29.2%; P <
0.05), increased SOD (36.4%; P < 0.05) and CAT (43.6%; P < 0.05) compared with
hyperlipidemia group. In conclusion, PU3 may be potential sources of natural
antioxidant to protecting against the liver damage of oxidative stress induced by
cholesterol-rich diet.
2018-Antioxidant activity of purified ulvan in hyperlipidemic mice.pdf