Spirulina Extract-impregnated Alginate-PCL Nanofiber Wound Dressing for Skin Regeneration
學生姓名:
曾揚捷
指導教授:
江孟燦
學 號:
10732014
學期:
107下
摘 要:
In recent years, nanofibers have been developed and widely used in many products, such as cosmetics and
medical supplies. They can be fabricated from various synthetic or natural polymers and attached to bioactive
compounds. In previous research, polycaprolactone (PCL) nanofibers containing Spirulina extract were demonstrated
to be effective on dermal wound healing in a rat model. In this study, we fabricated Spirulina extract-alginate PCL
nanofibers using alginate, which has hydrophilic structures capable of holding large amounts of water, to support the
backbone of the nanofibers. The morphological characteristics,hydrophilicity, water absorbance, skin adhesiveness,
toxicity to human keratinocyte cells (HaCaT), and Spirulina extract emission over time were assessed. Alginate improved
the efficacy of Spirulina PCL nanofibers in moisture maintenance and adhesion ability, which highly affected recovery in the rat skin wound model. In conclusion, Spirulina extract-alginate PCL nanofibers could be considered a promising candidate for wound care.
medical supplies. They can be fabricated from various synthetic or natural polymers and attached to bioactive
compounds. In previous research, polycaprolactone (PCL) nanofibers containing Spirulina extract were demonstrated
to be effective on dermal wound healing in a rat model. In this study, we fabricated Spirulina extract-alginate PCL
nanofibers using alginate, which has hydrophilic structures capable of holding large amounts of water, to support the
backbone of the nanofibers. The morphological characteristics,hydrophilicity, water absorbance, skin adhesiveness,
toxicity to human keratinocyte cells (HaCaT), and Spirulina extract emission over time were assessed. Alginate improved
the efficacy of Spirulina PCL nanofibers in moisture maintenance and adhesion ability, which highly affected recovery in the rat skin wound model. In conclusion, Spirulina extract-alginate PCL nanofibers could be considered a promising candidate for wound care.
2017-Spirulina_Extract-impregnated_Alginate-PCL_Nanofiber_Wound_ Dressing_for_Skin_Regeneration.pdf