Pullulan-based dissolving microneedle arrays for efficient transdermal administration of drug.
學生姓名:
石穎達
指導教授:
黃意真
學期:
109下
摘 要:
Transdermal drug delivery systems (TDDS) are well-known within the pharmaceutical domain. Transdermal administration provides advantages such as improved dosage efficacy with controlled or prolonged drug delivery, enhanced patient compliance, and reduced systemic side effects. However, stratum carenum (SC) as the first barrier of the skin it allows only low molecular weight drug to penetrate into skin. SC limits transdermal delivery of larger molecules such as proteins. To overcome this issue, microneedle array (MN) is considered to be a safe and efficient method in TDDS in these decades. MN will penetrate SC and form a temporary micropores on skin so that drug could diffuse. In this study, dissolving microneedle (DMN) array, a kind of MN, were fabricated to incorporate the protein drug (FITC-BSA and insulin) into a polymeric matrix, pullulan (PL). Through texture analyzer, PL-DMN exhibited good mechanical properties, which enabled the perforation of human skin. Additionally, the secondary structure of drug in PL-DMN was stable which measured by circular dichroism(CD). The PL-DMN were non-cytotoxic towards human keratinocytes (HaCaT cell), being safe for skin application. This study demonstrates that PL-DMN may serve as a promising tool for efficient transdermal drug delivery.
3.17摘要-石穎達.pdf