Angiotensin I-Converting Enzyme Inhibitory Activities and 2 Molecular Docking analysis of Bioactive peptides from Fish Skin
學生姓名:
賴儷云
指導教授:
陳冠文
學期:
110上
摘 要:
Alaska pollack skins and Atlantic salmon (Salmo salar L.) skin were low price but can be developed into ACE inhibitory peptides (ACEIPs) by enzyme hydrolysis. This study was aimed to produce and characterize ACEIPs from extracted Alaska pollack skins and Atlantic salmon skin proteins. Alaska pollack skins protein and Atlantic salmon skin were hydrolyzed by commercial enzymes (Alcalase, Trypsin and Alcalase
and Papain, respectively) to obtain the hydrolysates with ACE inhibitory activities. ACE inhibitory peptides were successfully purified from the hydrolysates of Alaska pollack skins protein and Atlantic salmon skin collagen, respectively. The peptide sequences (GPLGVP, etc.) were purified and identified from Alaska pollack skins protein; GR, RER, GPR, AP and VR from Atlantic salmon skin collagen peptides
(SSCPs) and their in vitro ACE inhibitory activity assay revealed the IC50 values of 105.8 μM, 0.73, 0.89, 1.05, 0.06, and 0.332 mg/mL, respectively. These results indicated that ACE inhibitory peptides derived from Alaska pollack skins protein and Atlantic salmon skin collagen hydrolysates may be beneficial as antihypertensive compounds for use as functional food ingredients.
and Papain, respectively) to obtain the hydrolysates with ACE inhibitory activities. ACE inhibitory peptides were successfully purified from the hydrolysates of Alaska pollack skins protein and Atlantic salmon skin collagen, respectively. The peptide sequences (GPLGVP, etc.) were purified and identified from Alaska pollack skins protein; GR, RER, GPR, AP and VR from Atlantic salmon skin collagen peptides
(SSCPs) and their in vitro ACE inhibitory activity assay revealed the IC50 values of 105.8 μM, 0.73, 0.89, 1.05, 0.06, and 0.332 mg/mL, respectively. These results indicated that ACE inhibitory peptides derived from Alaska pollack skins protein and Atlantic salmon skin collagen hydrolysates may be beneficial as antihypertensive compounds for use as functional food ingredients.
專題討論摘要20211110_賴儷云.pdf