Algae Attenuates Atopic Dermatitis Symptoms by Modulating Immune Response in Mice
學生姓名:
黃璟瑀
指導教授:
吳彰哲
學期:
111上
摘 要:
Atopic dermatitis (AD) is an allergic skin disease accompanied by chronic inflammation that is characterized by severe itching, redness, dryness, and eczematous skin lesions and is associated with high serum level of immunoglobulin (Ig)E. It is common in children but can occur at any age. Although the pathogenesis of AD is not fully understood, it is known to be caused by immune dysregulation resulting from the complex interaction of environmental and genetic factors. Marine algae are abundant in many bioactive components, e.g. carbohydrates, proteins, minerals, polyphenols, and pigments. Polysaccharides, such as fucoidans in brown algae, ulvans in green algae and carrageenans in red algae. AD-associated chemokines including thymus and activation-regulated chemokine (TARC) and regulated upon activation, normal T-cell expressed and secreted chemokine (RANTES), were inhibited by polysaccharides from marine algae in human
keratinocytes. Sargassum horneri ethanolic extract (SHE) could ameliorate AD by inhibiting the development of eczematous lesions, by suppressing TEWL, serum IgG1, and IgG2a levels, hyperkeratosis, and epidermal hyperplasia, in the skin and ear by suppressing the infiltration of inflammatory cells in HDM/DNCB-induced AD NC/Nga mice models. Seaweed fulvescens extract (SF) showed anti-AD effects in the Df-induced AD32 like mouse model and in TNF-α and IFN-γ mixture-stimulated HaCaT keratinocytes via inhibition of proinflammatory cytokine production and expression. These effects of SF in AD were attributed to the inhibition of the STAT1 signaling pathway. Thus, seaweed extracts could contribute to the development of preventive and therapeutic agents for inflammatory diseases such as AD.
keratinocytes. Sargassum horneri ethanolic extract (SHE) could ameliorate AD by inhibiting the development of eczematous lesions, by suppressing TEWL, serum IgG1, and IgG2a levels, hyperkeratosis, and epidermal hyperplasia, in the skin and ear by suppressing the infiltration of inflammatory cells in HDM/DNCB-induced AD NC/Nga mice models. Seaweed fulvescens extract (SF) showed anti-AD effects in the Df-induced AD32 like mouse model and in TNF-α and IFN-γ mixture-stimulated HaCaT keratinocytes via inhibition of proinflammatory cytokine production and expression. These effects of SF in AD were attributed to the inhibition of the STAT1 signaling pathway. Thus, seaweed extracts could contribute to the development of preventive and therapeutic agents for inflammatory diseases such as AD.
專題討論_摘要_2022.09.21_黃璟瑀.pdf