Anti-inflammatory and immunomodulatory potential of brown algal polysaccharides
學生姓名:
蔡翊菻
指導教授:
黃崇雄
學期:
114下
摘 要:
This study integrates two investigations on the biomedical potential of brown seaweed polysaccharides, specifically alginates and fucoidans, in modulating inflammation and allergic responses. The first study characterized an alginate extracted from Ericaria amentacea, which featured high G-block content, demonstrated strong antioxidant activity, and downregulated the iNOS/NO pathway. It also showed significant anti-inflammatory properties by reducing LPS-induced pro-inflammatory cytokines (IL19 6 and IL-8) in human fibroblasts. The second study compared the effects of fucoidans and alginates from Sargassum graminifolium on OVA-induced food allergy in mice. Both polysaccharides were found to alleviate allergic symptoms and decrease IgE levels, while also improving gut microbiota composition and increasing short-chain fatty acid production, thereby enhancing intestinal barrier function. Collectively, these findings highlight the potential of seaweed-derived polysaccharides as bioactive ingredients for functional foods or therapeutic agents targeting inflammatory and allergic conditions
蔡翊菻.pdf